This is a fantastic original color model sheet of Jan from Space Ghost (1966). The model sheet is dated 1966 and was probably done as presentation of licensing artwork for the original series. Artwork such as this is extremely rare. The entire piece measures 10.5" x 12.5" and the largest image of Blip in the top left measures 7" x 1.5". This artwork is featured in Jerry Beck's book "The Hanna-Barbera Treasury" (page 134).
This piece was exhibited at the Norman Rockwell Museum in Stockbridge, MA for their 2017 exhibit, "Hanna Barbera: The Architects of Saturday Morning."